Parathyroidectomy or cinacalcet: Do we still not know the best option for graft function in kidney-transplanted patients? A meta-analysis
نویسندگان
چکیده
Background Tertiary hyperparathyroidism occurs in 25% to 50% of kidney-transplanted patients. Indication parathyroidectomy is now discussed, since the calcimimetic agent, cinacalcet, an alternate option. The effects either these treatments on graft function remain controversial, studied only small cohorts showing decrease or absence modification. We performed a meta-analysis evaluate evolution after surgical medical treatment. Methods Studies assessing tertiary cinacalcet introduction were enrolled into quantitative analysis using Pubmed, Embase, and Cochrane databases following Preferred Reporting Items for Systematic Reviews Meta-Analysis reporting guidelines. Among 68 screened studies, 18 had no missing data included statistical analyses. random effect determine changes serum creatinine estimated glomerular filtration rate. Results Seven studies 6 and/or 12 months 13 administration included. Meta-analysis found significant variations (6 314 patients) rate (2 105 patients). No variation was (10 404 149 A heterogeneity between (P < .01, Cochran’s Q) found. Conclusion shows that do not significantly impair patients with hyperparathyroidism. However, selected partially explained by lack consensual definition hyperparathyroidism, limits conclusions all previously published series.
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ژورنال
عنوان ژورنال: Surgery
سال: 2021
ISSN: ['0039-6060', '1532-7361']
DOI: https://doi.org/10.1016/j.surg.2021.02.048